Wall Street dives into Neurocrine Biosciences By Investing.com

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In a competitive and ever-evolving biopharmaceutical landscape, Neurocrine (NASDAQ:) Biosciences, Inc. (NASDAQ: NBIX) stands out with its focus on neurological and endocrine-related diseases and disorders. Analysts have been closely monitoring the company’s performance and pipeline developments, providing insights that are crucial for investors looking to understand the potential risks and rewards associated with NBIX.

Performance in Different Markets

The core product of Neurocrine Biosciences, Ingrezza, used to treat Tardive Dyskinesia, continues to perform robustly, though concerns have been raised about its long-term potential not meeting Street expectations despite short-term durability. The company’s focus on diversifying its revenue base is marked by R&D efforts, with multiple Phase 2 readouts expected in 2024 and several Phase 1 initiations planned for its muscarinic portfolio.

Product Segments and Pipeline

Neurocrine’s pipeline is a mix of promise and setbacks. The company’s “20 in 5” goal is to produce 20 developmental candidates in the next five years, which should also enhance their ability to assess external business development opportunities. The recent success of crinecerfont in phase III trials for congenital adrenal hyperplasia (CAH) has been a silver lining, potentially setting the stage for a new blockbuster product. Neurocrine anticipates significant catalysts in 2024 that could de-risk its historically risky pipeline, including five Phase 2 top-line reports. A strong patient advocacy network for CAH suggests a potentially robust launch for crinecerfont due to the lack of available therapies.

Competitive Landscape and Market Trends

Neurocrine operates in a highly competitive market, where innovation and timely product development are key. The variety in the pipeline positions Neurocrine competitively in the neurology space, with new treatments and strategic acquisitions speculated to bolster its pipeline. Analysts also view the company as a potential acquisition target itself, given its strong product Ingrezza and promising pipeline candidates.

Regulatory Environment and Customer Base

The regulatory environment remains a critical factor for Neurocrine. The company has received Breakthrough Status for CAH, which is a significant milestone that could expedite its drug development process. Analysts anticipate that the company will navigate through these milestones effectively, which could lead to significant value appreciation.

Management and Strategy

Under new leadership, Neurocrine has been refocusing on validated biology and lower-risk innovation. The strategic pivot is expected to leverage the company’s core strengths and improve its risk profile, as reflected by the maintained “Overweight” rating by analysts.

External Factors

The Inflation Reduction Act (IRA) continues to be a point of concern for analysts, with potential impacts on long-term Ingrezza prospects due to changes in drug pricing and reimbursement. Moreover, penetrating the Long-Term Care (LTC) market is associated with high costs.

Upcoming Product Launches

Crinecerfont’s upcoming launch, following a likely approval towards the end of 2024, is highly anticipated. The drug’s potential for treating CAH could position it as a standard treatment with a significant market share.

Stock Performance

Neurocrine’s stock has seen fluctuations in response to pipeline developments and market conditions. Analysts have provided varied price targets, reflecting their individual assessments of the company’s risk-reward scenario and future prospects.

Bear Case

Is Neurocrine Biosciences facing significant pipeline risks?

Despite the breadth of assets targeting muscarinic mechanisms and the potential for success, Neurocrine has experienced pipeline setbacks, most notably with the failure of ‘352 for epilepsy and ‘864 for anhedonia. These failures limit the company’s ability to diversify beyond Ingrezza, raising concerns about its long-term growth potential. Analysts have adjusted their price targets accordingly, reflecting increased risk perceptions and the need for strategic decisions to rebuild the pipeline.

Will Neurocrine’s reliance on Ingrezza affect its growth prospects?

While Ingrezza’s strong sales continue, there is skepticism about the drug’s ability to sustain long-term growth, particularly with the potential impact of the IRA. The company’s reliance on this single product could pose risks to its valuation if pipeline developments do not yield successful new treatments.

Bull Case

Can Neurocrine Biosciences capitalize on its recent clinical successes?

The success of crinecerfont in phase III trials for CAH has been a significant boost for Neurocrine. Analysts believe that this drug has the potential to become a standard treatment for CAH, with a high probability of regulatory approval. The company’s strategic acquisitions and focus on low-risk innovation could further enhance its growth trajectory.

Is the market underestimating Neurocrine’s potential catalysts?

Upcoming catalysts, including phase II readouts for ‘352 in focal onset seizures and the muscarinic program, could provide significant upside for Neurocrine. Analysts remain optimistic about the company’s ability to deliver on these fronts, which could lead to a revaluation of NBIX shares.

SWOT Analysis


– Strong sales performance of Ingrezza.

– Positive phase III trial results for crinecerfont in CAH.

– Strategic focus on low-risk innovation and validated biology.


– Pipeline setbacks with the failure of two mid-stage programs.

– Heavy reliance on Ingrezza for revenue.

– Potential impact of IRA on long-term prospects.


– Market expansion through strategic acquisitions.

– Upcoming product launches and pipeline readouts.

– Untapped market potential for Tardive Dyskinesia treatment.


– Competitive market with rapid innovation.

– Regulatory hurdles and insurance coverage issues.

– Execution risks in commercializing new products.

Analyst Targets

– Barclays Capital Inc.: Overweight rating with a price target of $125.00 (December 7, 2023).

– BMO Capital Markets Corp.: Market Perform rating with a price target of $100.00 (December 6, 2023).

– RBC Capital Markets: Sector Perform rating with a price target of $128.00 (November 1, 2023).

– Piper Sandler: Neutral rating with a price target of $100.00 (November 1, 2023).

The analysis timeframe spans from September to December 2023.

InvestingPro Insights

In the context of Neurocrine Biosciences’ strategic maneuvers and market performance, real-time metrics and InvestingPro Tips provide a deeper understanding of the company’s financial health and stock behavior. With a focus on neurological and endocrine-related diseases, NBIX’s financials and stock trends reflect its operational strategies and market position.

InvestingPro data indicates a robust market capitalization of $11.61 billion, which underscores the company’s significant presence in the biopharmaceutical industry. The P/E ratio stands at 60.36, suggesting investors are willing to pay a premium for the company’s earnings, potentially due to expectations of future growth. Adjusted for the last twelve months as of Q3 2023, the P/E ratio shows a more favorable figure at 37.97, reflecting an adjustment that may be more indicative of the company’s ongoing earnings potential.

With a PEG ratio of 0.29 for the same period, NBIX appears to offer growth at a reasonable price when considering its earnings growth rate. This metric is particularly relevant for investors looking for growth opportunities at a potentially undervalued price point. Additionally, the company’s revenue growth of 28.46% during the last twelve months as of Q3 2023 demonstrates a strong upward trajectory, which is a positive signal for investors seeking companies with increasing revenue streams.

InvestingPro Tips highlight that Neurocrine Biosciences yields a high return on invested capital and net income is expected to grow this year. These insights are especially valuable as they suggest the company’s investments are generating returns above the average cost of capital, and that its profitability is on an upward trend. Notably, nine analysts have revised their earnings upwards for the upcoming period, indicating a consensus shift towards a more optimistic outlook on the company’s financial performance.

For investors interested in more detailed analysis, there are additional InvestingPro Tips available, offering a comprehensive look at various aspects of NBIX’s financial and stock performance. Subscribers can access these tips at InvestingPro, with an exclusive Cyber Monday deal providing up to 60% off, plus an extra 10% off a 2-year subscription using the promo code research23. This offer is a timely opportunity to leverage the full suite of InvestingPro’s analytical tools and insights.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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